(8.1) All pregnancies have a risk of birth defect, loss, or other adverse outcomes.
FluLaval Tetra Fluzone® Quadrivalent Flucelvax® Quad (new for 2-8 year olds for 2021-2022) 5 years to 64 years Standard-dose quadrivalent (QIV) FluLaval Tetra Fluzone® Quadrivalent Flucelvax® Quad Afluria® Tetra (new for 2021-2022) 65 years and older High-dose quadrivalent (QIV-HD) Adjuvanted trivalent (TIV-adj) Standard-dose quadrivalent . Quadrivalent GlaxoSmithKline 0.5 mL single-dose prefilled syringe — ≤0.05 ≥3 yrs No IM† FluLaval Quadrivalent ID Biomedical Corp. of Quebec (distributed by GlaxoSmithKline) 5.0 mL multi-dose vial <25 ≤0.3 ≥3 yrs No IM† Fluzone Quadrivalent Sanofi Pasteur 0.25 mL single-dose prefilled syringe — § 6-35 mos No IM† Healthcare providers are encouraged to register women by calling 1-888-452-9622. Flulaval Quadrivalent Influenza Vaccine Description. FluLaval was previously approved for people 3 years of age and older. Injection-site (local) and systemic reaction data will be assessed on . If a child receives a dose of trivalent inactivated influenza vaccine as their first dose, The purpose of this pregnancy registry study is to detect and describe abnormal pregnancy outcomes in women intentionally or unintentionally vaccinated with any of GlaxoSmithKline (GSK) Biologicals' seasonal Inactivated Influenza Vaccines (sIIVs): Fluarix, FluLaval, Fluarix Quadrivalent and FluLaval Quadrivalent. Flulaval Quadrivalent / / IM . . The company makes trivalent and quadrivalent vaccines: Fluarix, Fluarix Quadrivalent, Flulaval, and Flulaval Quadrivalent, all of which are approved for ages 3 and older. June 29, 2018 Approval Letter - FluLaval Quadrivalent July 7, 2017 Approval Letter - FluLaval Quadrivalent To include the 2017-2018 United States formulation and associated labeling revisions. A: On November 18, 2016, the FDA approved an extension of the age range of FluLaval Quadrivalent IIV to include children 6 through 35 months of age.
This study examined the safety and immunogenicity of a quadrivalent high-dose split-virion inactivated influenza vaccine (IIV4-HD). Vaccines are considered one of the greatest public health achievements of the 20th century and the effectiveness of vaccines in controlling the spread of and even eradicating a variety of infectious diseases is widely acknowledged. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to FLUARIX QUADRIVALENT during pregnancy.
FluLaval Quadrivalent is approved for ages ≥6 months. Quadrivalent vaccines have broader coverage against influenza B than Trivalent vaccines.
FLULAVAL TETRA (2020-2021) GlaxoSmithKline Approved: Page 4 of 27 INDICATIONS AND CLINICAL USE FLULAVAL TETRA is a quadrivalent vaccine indicated for active immunization of adults and children from 6 months of age for the prevention of influenza disease caused by influenza virus types A and B contained in the vaccine. 8.1 Pregnancy 8.2 Lactation 8.4 Pediatric Use 8.5 Geriatric Use 11 DESCRIPTION 12 CLINICAL PHARMACOLOGY 12.1 .
pregnancy, due to the risk of influenza related morbidity.5 The safety of inactivated influenza vaccine during pregnancy has been reviewed and has not shown evidence of harm to the mother or fetus.5 Lactation Breastfeeding women should be immunized. Any age-appropriate IIV4 or RIV4 may be given in any trimester. • Pregnancy: There is a pregnancy exposure registry that monitors outcomes in women exposed to FLUCELVAX QUADRIVALENT during pregnancy. Currently Fluzone Quadrivalent 0.25 mL or 0.5 mL (Sanofi Pasteur), FluLaval Quadrivalent 0.5 mL (GSK), Fluarix Quadrivalent 0.5 mL (GSK), and Afluria Quadrivalent 0.25 mL (Seqirus) are the only inactivated influenza vaccines approved for use in children age 6 months through 23 months. 7. options (FluLaval and Fluzone); however, these two vaccines are administered at different volumes, so healthcare providers should take caution to administer the correct volume depending on the vaccine used (see below for more information). For non-pregnant adults, July and August should be avoided unless there is There were no developmental toxicity studies of FLUAD QUADRIVALENT performed in animals. Fever has also been seen in children 5 to younger than 9 years of age. FluLaval Quadrivalent Standard-dose IIV4 (GSK) Previously licensed for ages ≥3 years; since November 2016 licensed for ≥6 months One of only two influenza vaccines approved for children 6 through 35 months of age Dose volume is same as that for all ages (0.5mL) Previously 6 through 35 month-olds recommended to receive smaller
GSK voluntarily initiated this recall because of the potential that .
A pregnancy exposure registry has been set up to collect data on pregnancy outcomes and newborn health status outcomes following vaccination with Flulaval during pregnancy.
Table 1 footnotes. Women only: Are you pregnant or is there a chance you could become pregnant during the next month? You will need to talk about the benefits and risks to you and the baby.
The approved dose volume is 0.5 mL per dose for all persons aged ≥6 months. GSK's Flulaval Quadrivalent is an inactivated influenza virus vaccine prepared from viruses propagated in hens' eggs. A quadrivalent inactivated influenza virus vaccine produced using the Madin Darby canine kidney cell line has been approved in the EU (Flucelvax ® Tetra) and USA (Flucelvax Quadrivalent ®; QIVc hereafter) for the prevention of influenza in adults and children. There are two recombinant influenza vaccines, Flublok® (RIV3) and Flublok® Quadrivalent (RIV4). . FLULAVAL TETRA (2019-2020) GlaxoSmithKline Approved: 25 April 2019 Page 4 of 27 INDICATIONS AND CLINICAL USE FLULAVAL TETRA is a quadrivalent vaccine indicated for active immunization of adults and children from 6 months of age for the prevention of influenza disease caused by influenza virus types A and B contained in the vaccine. FluLaval Quadrivalent is approved for use in persons aged 6 months and older. • Fluarix Quadrivalent: 0.5mL • FluLaval Quadrivalent: 0.5 mL • Fluzone Quadrivalent: 0.25 mL Dose volume is distinct from number of doses needed: • Ahild aged 6 months through 8 years who needs 2 doses c — • (for example, if a first -time vaccinee) — • and who gets 0.5mL FluLaval Quadrivalent for a first dose— • Schedule Fluzone® Quadrivalent FluLaval . There is a quadrivalent flu shot that can be given to children as young as 6 months old.
• FluLaval Quadrivalent (IIV4, GSK) 0.5 mL • Fluarix Quadrivalent (IIV4, GSK) 0.5 mL • Afluria Quadrivalent (IIV4, Seqirus) 0.25 mL • Fluzone Quadrivalent (IIV4, Sanofi Pasteur) 0.25 mL or 0.5 mL • Fluzone Quadrivalent 0.25 mL prefilled syringes will not be available for 2020-21
The viruses are inactivated with ultraviolet light treatment followed by formaldehyde treatment, purified by centrifugation, and disrupted with sodium .
There is a lot of evidence to show that flu shots can be safely given to women during pregnancy. . A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins. FLULAVAL is an inactivated influenza virus vaccine indicated for active immunization of adults 18 years of age and older against influenza disease caused by influenza virus subtypes A and type B contained in the vaccine. Different vaccines are approved for different age groups. Use FluLaval Quadrivalent (influenza virus vaccine (inactivated)) as ordered by your doctor. pregnant persons in third trimester. I. FLULAVAL TETRA is a quadrivalent vaccine indicated for active immunization of adults and children from 6 months of age for the prevention of influenza disease caused by influenza virus types A and B contained in the vaccine.
This creates an additional option for vaccination of children 6 months through 35 months in addition to the . Receipt of an anti-influenza antiviral drug in the previous 48 hours. The . Afluria, quadrivalent: Flulaval, quadrivalent. pregnant women or nursing mothers. Background and Objectives for the Systematic Review. Pregnancy Exposure Registry. Non-pregnant 2 to 49 years L N Y N Y *GSK= GlaxoSmithKline †PFS=prefilled syringe FluLaval®, Fluarix ®, and Fluzone may contain trace amounts of formaldehyde FluMist® contains porcine-derived gelatin and monosodium glutamate
The approved dose volume for children aged 6 through 35 months is either 0.25 mL or 0.5 mL per dose. All flu vaccines in the United States for the 2021-2022 season are quadrivalent vaccines. or Fluarix Quadrivalent or FluLaval Quadrivalent during pregnancy or within 28 days preceding conception ) with abnormal pregnancy outcomes. FluLaval Quadrivalent (GSK) 0.5 ml syringe, 5 ml MD vial > 6 months . Pregnant Women: The safety of FLULAVAL . Table 1 footnote a. IIV3-SD formulations (Agriflu ® (6 months and older), Fluviral ® (6 months and older), and Influvac ® (3 years and older)) are authorized but will not be available for use in Canada during the 2021-2022 influenza season.. Return to footnote a referrer. There are insufficient human data to establish whether there is a vaccine-associated risk with use of FLUAD QUADRIVALENT in pregnancy. pregnant women, nursing mothers, and children.
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